Four new cyclic diarylheptanoids, casuarinols A-C ( 1 – 3 ) and casuarinolide A ( 4 ), together with six known ones ( 5 – 10 ), were isolated from the roots of Casuarina equisetifolia . Structures were elucidated by extensive spectroscopic analysis, theoretical conformational, and electronic circular dichroism analyses. Casuarinol C ( 3 ) is a novel cyclic diarylheptanoid-aldehyde adduct. Casuarinolide A ( 4 ) represents the first structure of a seco -cyclic diarylheptanoid. Compounds 1 – 9 were evaluated for their anti-influenza A virus (IAV) activity against A/WSN/33 (H1N1). (-)-( M )-11-Oxo-3,12 R ,17-trihydroxy-9-ene-[7,0]-metacyclophane ( 5 ) displayed significant anti-IAV activity with an IC_{50} value of 8.64 ± 2.49 μM and a CC_{50} higher than 100 μM.
Discovery of Cyclic Diarylheptanoids as Inhibitors against Influenza A Virus from the Roots of Casuarina equisetifolia
[Category] 신종인플루엔자,
[Source] pubmed
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