Four new cembrane diterpenes, 1,13-di- epi -13-acetoxy launine P ( 1 ), 13-oxo-thunbergol ( 2 ), isocrassumol B ( 3 ) and 7α, 8α-sarcophine ( 4 ), together with two known launine P ( 5) and sarcophytonin B ( 6 ), were isolated from the extract of the South China Sea soft coral Sarcophyton trocheliophorum . The structures were elucidated by spectroscopic analysis, ECD analysis and comparison with literature data. All compounds were tested for their antimicrobial activity and antiviral activity. Compounds 1 , 2 and 5 were found to exhibit weak antibacterial activity, while 6 showed strong inhibition activity against Staphylococcus aureus and Bacillus subtilis (MIC<0.5 µg/mL). Compounds 2 showed moderate inhibitory effect against influenza A viruses H1N1 with IC_{50} of 17.8 μM.
【저자키워드】 soft coral, Sarcophyton trocheliophorum, antibacterial and antiviral activity, cembranoid.,