Abstract
Currently, a plethora of information has been accumulated concerning COVID-19, including the transmission pathway of SARs-CoV-2. Thus, we retrieved targets associated with the development of COVID-19 via PubChem. A total of 517 targets were identified, and signaling pathways responded after infection of SARs-CoV-2 in humans constructed a bubble chart using RPackage. The bubble chart result suggested that the key signaling pathway against COVID-19 was the estrogen signaling pathway associated with AKT1, HSP90AB1, BCL2 targets. The three targets have the strongest affinity with three ligands-Akti-1/2, HSP990, S55746, respectively. In conclusion, this work provides three key elements to alleviate COVID-19 symptoms might be anti-inflammatory effects on SARs-CoV-2-infected lung cells.
Keywords: AKT1-HSP90AB1-BCL2; Akti-1/2-HSP990-S55746; Anti-inflammatory effects; COVID-19; Estrogen signaling pathway.
【저자키워드】 COVID-19, Anti-inflammatory effects, AKT1-HSP90AB1-BCL2, Akti-1/2-HSP990-S55746, Estrogen signaling pathway., 【초록키워드】 Anti-inflammatory effects, Human, Infection, AKT1, Estrogen, Transmission, pathway, target, targets, Hsp90, signaling pathway, information, COVID-19 symptoms, BCl2, Pathways, COVID-19 symptom, the strongest, S55746, PubChem, plethora, anti-inflammatory effect, HSP90AB1, lung cells, element, provide, suggested, concerning, alleviate, accumulated, retrieved, 【제목키워드】 in silico, Signaling,