Abstract
Background: It is still unknown whether COVID-19 vaccines induce a prothrombotic state or increase the hypercoagulable condition in subjects with a predisposition to thrombosis.
Objectives: We evaluated the coagulation profile in a series of healthy subjects who received the first dose of the BNT162b2 or the ChAdOx1 vaccines and assessed whether hypercoagulability developed.
Patients/methods: Volunteers among the staff of the University of Padua or health care professionals in the Padua University Hospital who had received either the ChAdOx1 or BNT162b2 vaccine in the previous 10 ± 2 days were eligible. A cohort of unvaccinated volunteers among family members of the University staff acted as control group. Global coagulation monitoring was assessed by whole blood rotational thromboelastometry, whole blood impedance aggregometry and thrombin generation. Platelet count was also obtained.
Results: One hundred and ninety subjects were enrolled: 101 (53.2%) received the ChAdOx1 vaccine and 89 (46.8%) the BNT162b2 vaccine. Twenty-eight non-vaccinated subjects acted as controls. Thromboelastometry parameters were all comparable among groups. Thrombin receptor activating peptide (TRAP)-, ADP- and ASPI-induced platelet aggregation were similar among groups, as well as platelet count. Endogenous thrombin potential (ETP) was comparable among groups. The results were confirmed after controlling for age, gender and hormonal. Considering women taking combined oral contraceptives or thrombophilia carriers, no differences were detected in thromboelastometry or thrombin generation parameters between subjects who received ChAdOx1 vs. BNT162b2 vaccines.
Conclusions: No significant activation of fibrinogen-driven coagulation, plasma thrombin generation or clinically meaningful platelet aggregation after ChAdOx1 or BNT162b2 vaccination was observed.
Keywords: COVID-19; SARS-Cov-2; Thrombin generation; Thrombophilia; Vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Thrombophilia, Thrombin generation, 【초록키워드】 BNT162b2 vaccine, COVID-19 vaccine, vaccination, Health care, thrombosis, peptide, Gender, Coagulation, Thrombophilia, BNT162b2, Cohort, COVID-19 vaccines, Health, Whole blood, Platelet, plasma, fibrinogen, age, receptor, women, ChAdOx1 vaccine, university, Care, ChAdOx1, hypercoagulability, Platelet count, hypercoagulable, thrombin, platelet aggregation, Activation, control group, subject, healthy subjects, carriers, first dose, no difference, no differences, oral contraceptives, aggregation, oral contraceptive, professional, BNT162b2 vaccines, prothrombotic state, predisposition, TRAP, parameter, ChAdOx1 vaccines, Volunteer, endogenous, controls, thrombin receptor, clinically, evaluated, induce, comparable, groups, healthy subject, activating, ADP, eligible, 【제목키워드】 pilot study,