Abstract
Children with cystic fibrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID-19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with significant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2-related severe lower respiratory infection within a period of 2 mo, requiring high-flow nasal oxygen support. Both children had 3 rd pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding.
Keywords: Cystic fibrosis; Poor lung health; Prolonged viral shedding; SARS-CoV-2.
【저자키워드】 SARS-CoV-2., cystic fibrosis, prolonged viral shedding, Poor lung health, 【초록키워드】 COVID-19, SARS-CoV-2, Respiratory failure, intensive care, severe COVID-19, Pneumonia, SARS-COV-2 infection, children, COVID-19 severity, High-flow nasal oxygen, Noninvasive ventilation, lung, Lung disease, fibrosis, oxygen, diabetes, respiratory infection, Asymptomatic, morbidity, cystic fibrosis, prolonged viral shedding, recurrence, mild infection, Prolonged, chronic lung disease, severe disease, Support, symptomatic disease, clearance, allergic bronchopulmonary, allergic bronchopulmonary aspergillosis, bronchopulmonary aspergillosis, described, develop, diagnosed, Poor, diabete, clearance of SARS-CoV-2, Cystic, 【제목키워드】 SARS-CoV-2, respiratory, Poor, Cystic,