Abstract
Amidst the Coronavirus Disease 2019 (COVID-19) pandemic, vaccination against severe acute respiratory syndrome 2 (SARS-CoV-2) is recommended for everyone over 18 years in South Korea, with the exception of pregnant women. Unexpected adverse cutaneous reactions after the COVID-19 vaccination have been recently reported. Cutaneous small-vessel vasculitis (CSVV) predominantly affects small blood vessels, defined as small intraparenchymal arteries, arterioles, capillaries, and venules, without any detectable involvement of non-cutaneous organs. We report five cases of CSVV after the ChAdOx1 COVID-19 vaccination in 44- to 68-year-old women. The symptoms commonly appeared within 2 days after vaccination. The lesion was localized to the lower limbs in four patients and spread to the upper limbs in one patient. All patients demonstrated a favorable response to oral methylprednisolone, antihistamines, and topical steroids. Considering the importance of the COVID-19 vaccination, clinicians should be aware of CSVV as a potential adverse event. Further studies are required to elucidate the causative link and pathogenesis.
Keywords: COVID-19; ChAdOx1 COVID-19 vaccine; autoimmunity; vasculitis.
【저자키워드】 COVID-19, Autoimmunity, vasculitis., ChAdOx1 COVID-19 vaccine, 【초록키워드】 Methylprednisolone, coronavirus disease, SARS-CoV-2, Autoimmunity, Coronavirus disease 2019, vaccination, pandemic, Pathogenesis, Symptom, Steroids, pregnant women, Severe acute respiratory syndrome, COVID-19 vaccination, adverse event, Patient, Vasculitis, women, South Korea, ChAdOx1, Capillaries, lower limb, lower limbs, upper limb, Cutaneous Small-vessel Vasculitis, lesion, acute respiratory syndrome, Antihistamines, clinician, reaction, one patient, organs, arteries, small blood vessels, Affect, FIVE, Arterioles, upper limbs, defined, spread to, reported, detectable, required, demonstrated, 【제목키워드】 Cutaneous, report,