Abstract
It is now well known that patients with severe COVID-19 are at risk for developing invasive pulmonary aspergillosis (IPA). Nevertheless, the symptomatology of IPA is often atypical in mechanically ventilated patients and the radiological aspects of SARS CoV-2 pneumonia and IPA are difficult to differentiate. In this context, the significance of the presence of Aspergillus in respiratory tract samples (detected by culture, galactomannan antigen, or specific PCR) is not yet fully understood. Here we report two cases of intubated and mechanically ventilated ICU patients with SARS-CoV-2 pneumonia, in whom Aspergillus was detected in respiratory samples, who had a favorable outcome in the absence of antifungal treatment. These two cases highlight the difficulty of using the new definitions of COVID-19 associated pulmonary aspergillosis for routine management of patients.
Keywords: Antifungal treatment; Aspergillus fumigatus; COVID-19; Invasive pulmonary aspergillosis; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2., Aspergillus fumigatus, Antifungal treatment, Invasive pulmonary aspergillosis, 【초록키워드】 SARS CoV-2, SARS-CoV-2, severe COVID-19, Pneumonia, risk, outcome, mechanically ventilated patients, Antigen, PCR, Symptomatology, Culture, management, Patient, ICU Patients, SARS-CoV-2 pneumonia, Aspergillus, Respiratory samples, patients, Aspergillus fumigatus, Antifungal, Atypical, Antifungal treatment, Invasive pulmonary aspergillosis, pulmonary aspergillosis, Intubated, galactomannan, SARS CoV, difficulty, mechanically ventilated, respiratory tract samples, IPA, ICU patient, invasive, radiological, highlight, absence, respiratory tract sample, mechanically ventilated patient, 【제목키워드】 ICU, airway, treat,