Abstract
Objective(s): This prospective observational cohort study aimed to evaluate whether women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the first trimester of pregnancy are at higher risk of adverse obstetric and neonatal outcomes compared to negative patients.
Study design: Seromolecular testing for SARS-CoV-2 was performed at 12, 16, 21 weeks, and at delivery; the cohort was then subdivided into a first-trimester SARS-CoV-2-positive (case) group and a SARS-CoV-2-negative (control) group. The primary outcome was a composite adverse obstetric outcome, defined as the presence of either abortion, preterm delivery, preterm prelabor rupture of membranes, preeclampsia, intrauterine growth restriction, stillbirth; and a composite measure of adverse neonatal events, including either 1- and 5-min Apgar score ≤ 7, neonatal intensive care unit admission and congenital birth defects. Maternal symptoms and antibody titer were secondarily assessed.
Results: A total of 17 of 164 women tested positive for SARS-CoV-2 (10.3%) in the first trimester. One SARS-CoV-2-positive patient who gave birth at another hospital was excluded. Composite adverse obstetric outcome was observed in 6.2% (1/16) SARS-CoV-2-positive and 10.5% (11/105) SARS-CoV-2-negative women; composite adverse neonatal outcome in 12.5% (2/16) and 7.6% (8/105), respectively. In the newborns of women who had developed IgG antibodies, the same antibodies were detected in arterial cord blood and the nasopharyngeal swab tested negative for SARS-CoV-2. No maternal pneumonia or hospital admission due to coronavirus disease-19 were recorded.
Conclusion: Asymptomatic or mildly symptomatic women during the first trimester of pregnancy did not experience significantly more adverse events than SARS-CoV-2-negative women.
Keywords: COVID-19; SARS-CoV-2; outcome; pregnancy; vertical transmission.
【저자키워드】 COVID-19, SARS-CoV-2, outcome, Pregnancy, vertical transmission, 【초록키워드】 coronavirus disease, coronavirus, intensive care, Pneumonia, antibody, hospital, Infection, Transmission, Symptom, severe acute respiratory syndrome Coronavirus, cohort study, preeclampsia, Nasopharyngeal swab, Cohort, Newborn, Cord blood, Maternal, Pregnancy, Stillbirth, Coronavirus disease-19, Asymptomatic, IgG antibodies, symptomatic, adverse event, Patient, Antibody titer, Birth, vertical transmission, Hospital admission, women, Admission, patients, Blood, first trimester, abortion, Composite, Neonatal, Obstetric, preterm delivery, intrauterine growth restriction, acute respiratory syndrome, Primary outcome, APGAR score, higher risk, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, growth, positive, membranes, rupture, defined, tested, evaluate, significantly more, events, was performed, excluded, were recorded, prospective observational cohort, 【제목키워드】 SARS-COV-2 infection, Neonatal,