S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Published on
Journal: Organic & Biomolecular Chemistry
[저자] Hsien-Wei Yeh, Tzung-Sheng Lin, Hsiao-Wen Wang, Hou-Wen Cheng, Der-Zen Liu, Pi-Hui Liang
[Category] 신종인플루엔자,
Pubmed URL    [DOI] 10.1039/c5ob01376c    
[Source] pubmed

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

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