Abstract
Disseminated histoplasmosis is usually associated with immunosuppressive conditions like AIDS. People with respiratory distress syndrome secondary to SARS-CoV-2 pneumonia are vulnerable to bacterial infections. Additionally, coinfection with fungal pathogens should be considered as a differential diagnosis even in immunocompetent patients who remain on mechanical ventilation secondary to COVID-19. The case presents a 61-year-old immunocompetent man, admitted to the medical ward due to COVID-19 pneumonia. Despite appropriate therapy, the patient required transfer to the intensive care unit for invasive mechanical ventilation. He remained critically ill with worsening respiratory failure. Two weeks later, coinfection by disseminated histoplasmosis was detected. After immediate treatment with amphotericin B and itraconazole, the patient tolerated weaning from mechanical ventilation until extubation. Awareness of this possible fungal coinfection in immunocompetent patients is essential to reduce delays in diagnosis and treatment, and prevent severe illness and death.
Keywords: COVID-19; TB and other respiratory infections; adult intensive care; infectious diseases; pneumonia (infectious disease).
【저자키워드】 COVID-19, Infectious diseases, adult intensive care, TB and other respiratory infections, pneumonia (infectious disease)., 【초록키워드】 Treatment, respiratory infections, Respiratory distress syndrome, COVID-19 pneumonia, therapy, Infectious diseases, Respiratory failure, intensive care, mechanical ventilation, Pneumonia, intensive care unit, itraconazole, Diagnosis, extubation, Infectious disease, Coinfection, Critically ill, AIDS, Patient, Awareness, death, Pathogens, SARS-CoV-2 pneumonia, Bacterial infections, Intensive, differential diagnosis, fungal, Histoplasmosis, Invasive mechanical ventilation, distress, amphotericin B, respiratory distress, secondary to, Amphotericin, other respiratory infections, syndrome, transfer, worsening respiratory failure, weaning, fungal pathogens, immunosuppressive conditions, Prevent, the patient, remained, required, reduce, fungal pathogen, immunosuppressive condition, on mechanical ventilation, 【제목키워드】 Pneumonia, patient with COVID-19,