Abstract
Introduction: Sars-CoV-2 is a single-strained RNA virus belonging to Coronaviridae’s family. In pediatric age, the majority of patients is asymptomatic; however, several neurological manifestations associated with Sars-CoV-2 infection have been detected in a percentage of cases ranging from 17.3 to 36.4%. Acute disseminated encephalomyelitis (ADEM) has been recently included among the potential complications of Sars-Cov2 infection. The available data regarding pediatric patient show only one case.
Case report: We present a case regarding a 6-year-old patient suffering from Fisher-Evans syndrome who was given sirolimus and thalidomide therapy. After 10 days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of acute disseminated encephalomyelitis. His clinical course was favorable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture.
Conclusions: According to our knowledge, this is the second case of an acute disseminated encephalomyelitis following SARS-CoV-2 infection in a pediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher-Evans syndrome has probably contributed to a favorable evolution of ADEM, in contrast to other case described in the literature.
Keywords: ADEM; Autoimmune disease; Epilepsy; Fisher-Evans Syndrome; Headache.
【저자키워드】 epilepsy, Autoimmune disease, ADEM, Fisher-Evans Syndrome, Headache., 【초록키워드】 Evolution, therapy, knowledge, SARS-COV-2 infection, pediatric, Infection, epilepsy, headache, Symptoms, SARS-CoV2 infection, MRI, thalidomide, Autoimmune disease, Nasopharyngeal swab, Clinical course, Asymptomatic, Patient, Complication, age, RNA virus, Coronaviridae, immunosuppressive therapy, Sirolimus, Seizure, Acute disseminated encephalomyelitis, immunosuppressive, Encephalomyelitis, no symptoms, episode of, available data, syndrome, episode, neurological manifestation, first positive, Disseminated encephalomyelitis, cortisone, cortisone therapy, described, characterized, majority, contributed, had no, monosymptomatic, 【제목키워드】 pediatric, Infection, Patient, syndrome,