Abstract
Objectives: To explore the association between drug exposure and SARS-CoV-2 prognosis among elderly people living in long-term care facilities (LTC) DESIGN: We carried out a cross-sectional study among old people living in LTC that had a proven SARS-CoV-2 infection, including socio-demographic data, comorbidities and drug intake at the moment of the diagnosis. The study was focused on ACE2 inhibitors, ARA-II blockers, inhaled bronchodilators, oral corticoids, platelet antiaggregants, oral anti-coagulants, statins and Vitamin D.
Results: 1 306 individuals were included, with a mean age of 86.7 years, and 72.3% were females. The case fatality rate was 24.4%. Among the studied exposures platelet antiaggregants were the most prevalent (24.7%). After adjusting for propensity score, the intake of inhaled corticoids (OR 0.73; p=0.03) and statins (OR 0.65; p=0.03) were found to be protective factors of death, whereas ACE2 inhibitor showed an almost significant association (OR 0.73, p=0.07).
Conclusions: Considering the high prevalence of drug intake among elderly people, drug exposure may be an important Covid-19 disease modifier in LTC residents and should be considered when exploring prognostic risk factors associated to Covid-19.
Keywords: ACE2 inhibitors; Covid-19; SARS-CoV-2; drug exposure; inhaled corticoids; long-term care facilities; statins.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2 inhibitors, drug exposure, inhaled corticoids, long-term care facilities, statins., 【초록키워드】 ACE2, Vitamin D, Prognosis, cross-sectional, SARS-COV-2 infection, Comorbidities, Diagnosis, Comorbidity, risk factor, inhibitors, COVID-19 disease, Prevalence, cross-sectional study, Long-term care, Case fatality rate, death, Platelet, Inhaled, age, Vitamin, prognostic, inhibitor, corticoids, disease, Care, statins, association, Propensity score, moment, individual, Fatality rate, protective factor, intake, blockers, females, socio-demographic, corticoid, prevalent, carried, LTC, 【제목키워드】 drug, Care, COVID-19 prognosis, Exploratory analysis,