Abstract
Purpose: We aimed to investigate the clinical performance of edoxaban for the treatment of pulmonary embolism (PE) in hospitalized COVID-19 patients.
Methods: We conducted a retrospective analysis selecting hospitalized patients with COVID-19 admitted to our Institution from 20 May 2020 to 20 November 2020 with computer tomography (CT) detected PE at admission, treated with edoxaban after initial parenteral therapy. Clinical outcomes were compared between patients with and without ARDS at admission and between those with and without CT confirmed PE resolution.
Results: 50 patients were included. Mean follow-up was 42.5 ± 10 days. No baseline differences were found between patients with ARDS (30%) and those without ARDS at admission. Patients with PE resolution (84%) were younger ( P = 0.03 ), had a shorter duration of fondaparinux therapy (9.9 ± 3.8 vs 15.8 ± 7.5 days; P = 0.0015) and length of hospitalization (36 ± 8 vs 46 ± 9 days: P = 0.0023) compared with those without PE resolution. 2 patients experienced major bleedings. At multivariate analysis the time to edoxaban switch was the only predictor of the PE resolution (HR: 0.92; 95% C.I. 0.86 to 0.99 ) .
Conclusion: Edoxaban was an effective and safe treatment for acute PE in COVID-19 setting.
Keywords: ARDS; COVID-19; SARS-CoV-2; edoxaban; efficacy; pulmonary embolism; safety.
【저자키워드】 COVID-19, SARS-CoV-2, Efficacy, ARDS, Safety, Pulmonary embolism, edoxaban, 【초록키워드】 Treatment, ARDS, therapy, Hospitalization, computer tomography, outcome, hospitalized patients, clinical outcomes, clinical, Pulmonary embolism, Patient, Retrospective analysis, Follow-up, Admission, Multivariate analysis, Analysis, edoxaban, Safe, fondaparinux, hospitalized COVID-19 patients, institution, effective, initial, conducted, treated, hospitalized patient, baseline, patients with ARDS, those without PE, with COVID-19, 【제목키워드】 Treatment, Pulmonary embolism, hospitalized COVID-19 patient, edoxaban,