Abstract
Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
Keywords: SARS-CoV-2; T-cells response; immune memory; interferon gamma release assay.
All Keywords
【저자키워드】 SARS-CoV-2, immune memory, T-cells response, interferon gamma release assay, 【초록키워드】 T-cell Response, T-cells, interferon, peptide, immune, SARS-CoV-2 immunity, Serological assay, protective immunity, serological assays, immune memory, T-cell, Interferon-gamma, Stimulation, interferon gamma, complementary, peptide pools, MONITOR, 【제목키워드】 memory, T-cell, COVID-19 patient, Specific,
【저자키워드】 SARS-CoV-2, immune memory, T-cells response, interferon gamma release assay, 【초록키워드】 T-cell Response, T-cells, interferon, peptide, immune, SARS-CoV-2 immunity, Serological assay, protective immunity, serological assays, immune memory, T-cell, Interferon-gamma, Stimulation, interferon gamma, complementary, peptide pools, MONITOR, 【제목키워드】 memory, T-cell, COVID-19 patient, Specific,
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항원 특이적 T 세포는 SARS-CoV-2에 대한 보호 면역에 필수적입니다. 우리는 SARS-CoV-2 펩타이드 풀로 자극한 후 T 세포 반응을 모니터링하기 위해 반자동 전혈 인터페론-감마 방출 분석(WB IGRA)을 설정했습니다. 우리는 WB IGRA가 SARS-CoV-2 면역성을 평가하기 위한 혈청학적 분석을 보완한다고 보고합니다.
{{ 키워드: }} SARS-CoV-2; T 세포 반응; 면역 기억; 인터페론 감마 방출 분석.