Background The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the possible development of serious illness, and the possibility of severe obstetric outcomes highlight the importance of addressing SARS-CoV-2 infection in obstetric management. Methods and findings A cross-sectional study of pregnant women assisted in a high-risk maternity hospital in Brazil in 2020. All patients admitted for delivery or miscarriage care were tested for SARS-CoV-2 using polymerase chain reaction (PCR) and for immunoglobulin (I)gM, and/or IgG by immunochromatography. Clinical aspects and obstetric outcomes were analyzed. A total of 265 pregnant women were included in the study. There were 38 (14.4%) PCR positive cases during pregnancy, 12 (31.6%) on admission screening, and 71(27.2%) patients were IgM- and/or IgG-positive. Among the participants, 86 (32.4%) had at least one positive test during pregnancy. SARS-CoV-2 positive patients had greater contact with known positive patients (p = 0.005). The most frequently reported symptoms were runny nose, cough, loss of smell and taste, headache, and fever. There was also a 35% rate of asymptomatic infections and a 4.6% rate of severe or critical infections. Patients exposed or infected with SARS-CoV-2 had a higher incidence of preterm delivery, cesarean section, need for resuscitation in the delivery room, Apgar score <7 at 5 min, admission to the neonatal intensive care unit, and jaundice. Newborns with at least one positive test had a significantly greater need for phototherapy after delivery (p = 0.05). The results showed a high rate of positive tests among newborns (37.5%), which seems to be compatible with both neonatal and perinatal infection. Conclusions It is important to further investigate SARS-CoV-2 infection during pregnancy, including the clinical course and the possibility of adverse outcomes with impact on maternal and fetal health, regardless of the development of symptoms.
【초록키워드】 Brazil, immunochromatography, SARS-CoV-2, IgG, IgM, coronavirus, intensive care, cross-sectional, SARS-COV-2 infection, hospital, Infection, outcome, severe acute respiratory syndrome Coronavirus, cough, headache, Symptoms, adverse outcomes, adverse outcome, asymptomatic infections, pregnant women, Spread, polymerase chain reaction, Resuscitation, Newborn, Clinical course, Pregnancy, Health, infections, cross-sectional study, PCR, Immunoglobulin, clinical, management, Fever, Patient, asymptomatic infection, Cesarean section, incidence, Taste, Admission, Care, Critical, miscarriage, Contact, Neonatal, Obstetric, during pregnancy, Chain Reaction, contact with, preterm delivery, runny nose, maternity hospital, phototherapy, neonatal intensive care unit, Loss of Smell, acute respiratory syndrome, Participants, APGAR score, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, PCR positive, loss of smell and taste, Positive test, SARS-CoV-2 positive patients, jaundice, delivery room, highlight, polymerase chain, greater, tested, analyzed, significantly, positive patient, fetal, infected with SARS-CoV-2, reported symptom, SARS-CoV-2 positive patient, 【제목키워드】 hospital, outcome, clinical, Obstetric,