This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participants were selected randomly among primary health care center attendees in Palestine between November 1, 2020 and December 31, 2020. All serum samples were tested for total antibodies using an enzyme-linked immunosorbent assay (ELISA) test. IgM, IgG, and IgA-specific antibody titers were measured using ELISA. The overall prevalence (with 95% confidence intervals [CIs]) of SARS-CoV-2 total antibodies and specific antibodies were estimated. A multivariate regression model was used to assess the predictive factors for SARS-CoV-2-specific antibodies. The overall seroprevalence of SARS-CoV-2 antibodies was 24·0% (95% CI, 21·7%–26·5%). Seroprevalence was significantly higher among people living in south West Bank (adjusted Odds ratio [aOR], 2·22; 95% CI: 1·58–3·11), people who had COVID-19 symptoms (aOR, 3·92; 95% CI, 2·83–5·43), people with a COVID-19 contact history (aOR, 1·44; 95% CI, 1·03–2·03), patients with hypertension (aOR, 1·57; 95% CI, 1·06–2·33), and non-smokers (aOR, 0·47; 95% CI, 0·31–0·72). A total of 171 blood samples from SARS-CoV-2-positive patients were chosen at random for additional serological testing. Specific IgM, IgG, and IgA antibodies were positive in 14·0% (95% CI, 9·2%–20·2%), 88·3% (82·5%–92·7%), and 42·1% (34·6%–59·9%) of the samples, respectively. SARS-CoV-2 antibodies were common among PHC center attendees and were significantly associated to sex, smoking, and COVID-19 contact history. However, considering that almost three-quarters of this population remains susceptible, maintaining public health measures and encouraging access to immunization is critical in protecting this population.
【초록키워드】 COVID-19, SARS-CoV-2, IgG, IgM, Health care, cross-sectional, Seroprevalence, Sex, smoking, severe acute respiratory syndrome Coronavirus, hypertension, immunization, ELISA, Prevalence, Severe acute respiratory syndrome, enzyme-linked immunosorbent assay, Region, Health, SARS-CoV-2 antibodies, cross-sectional study, Primary Health Care, SARS-CoV-2 antibody, Serological testing, IgA, Regression model, Patient, Antibody titer, epidemiological data, total antibody, serological, COVID-19 symptoms, Care, Critical, SARS-CoV-2-specific antibodies, specific antibodies, Smokers, Coronavirus-2, Contact, COVID-19 symptom, Predictive, public health measure, SARS-CoV-2 specific antibody, acute respiratory syndrome, Factor, 95% CI, acute respiratory syndrome coronavirus, 95% confidence interval, Blood samples, enzyme, SARS-CoV-2 specific antibodies, IgA antibodies, public health measures, acute respiratory syndrome coronavirus-2, blood sample, participant, North, SARS-CoV-2-positive patients, random, positive, total antibodies, specific IgM, Specific, serum sample, susceptible, enzyme-linked immunosorbent, Randomly, West Bank, selected, tested, was used, significantly, specific antibody, adjusted, significantly higher, were measured, IgA antibody, SARS-CoV-2-positive patient, were assessed, 【제목키워드】 cross-sectional, Health, SARS-CoV-2 antibody,