COVID-19 pandemic has posed a severe healthcare challenge calling for an integrated approach in determining the clues for early non-invasive diagnostics of the potentially severe cases and efficient patient stratification. Here we analyze the clinical, laboratory and CT scan characteristics associated with high risk of COVID-19-related death outcome in the cohort of severely-ill patients in Russia. The data obtained reveal that elevated dead lymphocyte counts, decreased early apoptotic lymphocytes, decreased CD14+/HLA-Dr+ monocytes, increased expression of JNK in PBMCs, elevated IL-17 and decreased PAI-1 serum levels are associated with a high risk of COVID-19-related mortality thus suggesting them to be new prognostic factors. This set of determinants could be used as early predictors of potentially severe course of COVID-19 for trials of prevention or timely treatment.
【초록키워드】 COVID-19, Treatment, Stratification, Monocytes, Lymphocytes, Mortality, Trial, COVID-19 pandemic, Russia, outcome, diagnostics, Laboratory, lymphocyte, Cohort, Characteristics, healthcare, CT scan, Patient, Prognostic factors, predictor, determinants, PBMCs, high risk, IL-17, determinant, Non-invasive, increased expression, Serum level, serum levels, Severe case, COVID-19-related death, CD14, lymphocyte counts, dead, CD14+, apoptotic, JNK, approach, Course, elevated, 【제목키워드】 Patient, novel, prognostic, determinant, pilot study,