Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.
【저자키워드】 Infectious diseases, Diseases of the nervous system, 【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, respiratory diseases, Symptoms, Brain, Encephalitis, global pandemic, nervous system, Meningitis, Encephalopathy, Central nervous system, incidence, CNS, mechanism, Guillain-barrè syndrome, experimental model, Evidence, SARS-CoV-2 neuroinvasion, Peripheral nervous system, Neurological complication, skeletal, potential mechanism, These data, syndrome, potential mechanisms, Neurological diseases, experimental models, caused, were used, cause, muscular, 【제목키워드】 SARS-CoV-2, Complication, infection mechanism,