The sensitivity to rimantadine of the reproduction of influenza virus A/Texas/1/77 (H3N2) and A (H1N1) isolates Nos 897, 778 and 782, isolated from patients during an epidemic influenza outbreak in Moscow in the winter of 1977/1978 was compared. A (H3N2) virus proved to be more sensitive than the A (H1N1) viruses tested, as manifested by decreases of the infectious titre in ovo and of the haemagglutinin titre in MDCK cells.
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