Background/aim In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. Materials and methods Twenty-eight critically ill and laboratory-confirmed COVID-19 patients who were admitted to the intensive care unit (ICU) of Sakarya University, Medical Faculty were included in the study. Patients were divided into 2 groups: patients who received anti-A antibody (Ab) containing CP (BG O and B) and those who did not receive CP containing anti-A Ab (BG A and AB). Results Among the 28 patients, 13 patients received anti-A Ab containing CP (BG; B: 6, O: 7) and 15 patients did not receive anti-A Ab CP (BG; A: 13, AB: 2). Duration in ICU, the rates of mechanical ventilation (MV) support and vasopressor support, the case fatality rate, and the discharge rate were lower in patients who received CP containing anti-A Ab than not containing anti-A Ab CP. However, only the difference in the rate of MV support achieved statistically significance (P = 0.04) Conclusion In our study, it was observed that the efficiency of CP without anti-A antibody was lower than that of plasma containing anti-A antibody, although it was not statistically significant. This result is thought to be due to the anti-A antibody’s ability to block the ACE2 receptor. We believe that this hypothesis should be investigated in controlled studies with higher patient numbers.
【저자키워드】 COVID-19, convalescent plasma, Blood groups, 【초록키워드】 Treatment, convalescent plasma, Efficacy, intensive care, mechanical ventilation, antibody, intensive care unit, ACE2 receptor, ICU, Duration, Critically ill, Patient, Case fatality rate, plasma, Blood groups, university, patients, critically ill patients, Blood Group, Hypothesis, faculty, COVID-19 patient, Efficiency, Support, Critically ill patient, Fatality rate, material, discharge rate, laboratory-confirmed, vasopressor support, thought, Result, investigated, statistically significant, statistically, receive, diagnosed with COVID-19, 【제목키워드】 Blood groups, Blood Group, COVID-19 patient,