ABSTRACT There is growing evidence that coronavirus disease 2019 (COVID-19) affects males more severely than females, including compelling evidence indicating that biological sex is an important clinical factor influencing disease pathology and outcomes. In their recent article in mBio , S. Dhakal, C. A. Ruiz-Bedoya, R. Zhou, P. S. Creisher, et al. (mBio 12:e00974-21, 2021, https://doi.org/10.1128/mBio.00974-21 ) find further evidence to support this hypothesis as they interrogate biological sex differences in the pathogenesis and clinical features of COVID-19 in the golden Syrian hamster model. Their study probes SARS-CoV-2 infection in terms of loss of body mass, recovery, lung compromise, viral replication, inflammatory response, immune response, and, most importantly, the role of estrogen. They also demonstrate the value of a novel unbiased, quantitative chest computed tomography (CT) imaging approach. The golden Syrian hamster model holds a promising opportunity to further investigate how biological sex acts as a primary determinant in SARS-CoV-2 pathogenesis, as also demonstrated in this study.
【저자키워드】 COVID-19, SARS-CoV-2, Lung infection, viral infections, Sex difference, Syrian hamster, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, immune response, Pathogenesis, SARS-COV-2 infection, lung, Sex, Estrogen, Clinical features, outcomes, Computed tomography, Chest computed tomography, viral replication, male, Quantitative, SARS-CoV-2 pathogenesis, clinical feature, Evidence, Hypothesis, Inflammatory response, body mass, Support, primary determinant, disease pathology, probe, Affect, females, approach, mBio, demonstrated, 【제목키워드】 Model, hamster, Biological, role, difference,