Abstract Transmission electron microscopy has historically been indispensable for virology research, as it offers unique insight into virus function. In the past decade, as cryo‐electron microscopy (cryo‐EM) has matured and become more accessible, we have been able to peer into the structure of viruses at the atomic level and understand how they interact with the host cell, with drugs or with antibodies. Perhaps, there was no time in recent history where cryo‐EM was more needed, as SARS‐CoV‐2 has spread around the globe, causing millions of deaths and almost unquantifiable economic devastation. In this concise review, we aim to mark the most important contributions of cryo‐EM to understanding the structure and function of SARS‐CoV‐2 proteins, from surface spikes to the virus core and from virus‐receptor interactions to antibody binding.
【저자키워드】 COVID‐19, structural biology, SARS‐CoV‐2, cryo‐electron microscopy, cryo‐electron tomography, single‐particle analysis, 【초록키워드】 antibodies, spike, drug, virus, SARS‐CoV‐2, Spread, Antibody binding, Microscopy, Research, death, transmission electron microscopy, Interaction, host cell, atomic level, economic devastation, offer, SARS‐CoV‐2 proteins, globe, unique, 【제목키워드】 SARS‐CoV‐2, Microscopy, atomic,