COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, and anti-viral antibody responses in serum from 147 hospitalized COVID-19 patients. Autoantibodies are identified in approximately 50% of patients but in less than 15% of healthy controls. When present, autoantibodies largely target autoantigens associated with rare disorders such as myositis, systemic sclerosis and overlap syndromes. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection. Autoantibodies track with longitudinal development of IgG antibodies recognizing SARS-CoV-2 structural proteins and a subset of non-structural proteins, but not proteins from influenza, seasonal coronaviruses or other pathogenic viruses. We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins. Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.
【저자키워드】 antibodies, SARS-CoV-2, Autoimmunity, viral infection, 【초록키워드】 COVID-19, coronavirus disease, IgG, Autoimmunity, Coronavirus disease 2019, SARS-CoV2, immune response, Cytokines, Influenza, SARS-COV-2 infection, cytokine, non-structural proteins, clinical manifestations, Protein, serum, IgG antibody, IgG antibodies, autoantibodies, immune responses, Patient, Connective tissue diseases, structural proteins, Hospitalised patients, Systemic sclerosis, Autoimmune, structural protein, seasonal coronaviruses, seasonal coronavirus, autoantigen, hospitalized COVID-19 patient, SARS-CoV-2 proteins, autoantibody, myositis, Autoantigens, hospitalized COVID-19 patients, overlap, pathogenic viruses, healthy controls, disorder, anti-viral antibody, de novo, anti-cytokine, feature, anti-viral antibody responses, develop, proportion, less, magnitude, hospitalised patient, recognizing, cause, subset, anti-viral antibody response, positively correlated, with COVID-19, 【제목키워드】 IgG, autoantibody, hospitalized patient, with COVID-19,