The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibits high levels of mortality and morbidity and has dramatic consequences on human life, sociality and global economy. Neutralizing antibodies constitute a highly promising approach for treating and preventing infection by this novel pathogen. In the present study, we characterize and further evaluate the recently identified human monoclonal MD65 antibody for its ability to provide protection against a lethal SARS-CoV-2 infection of K18-hACE2 transgenic mice. Eighty percent of the untreated mice succumbed 6–9 days post-infection, while administration of the MD65 antibody as late as 3 days after exposure rescued all infected animals. In addition, the efficiency of the treatment is supported by prevention of morbidity and ablation of the load of infective virions in the lungs of treated animals. The data demonstrate the therapeutic value of human monoclonal antibodies as a life-saving treatment for severe COVID-19 infection. Here, using the K18-hACE2 transgenic mice model, the authors report the in vivo efficacy of a fully human neutralizing antibody against SARS-CoV-2 and show that when administered before or up to 3 days post infection, treated mice do not exhibit disease symptoms while 80% of control animals succumb to the infection.
【저자키워드】 SARS-CoV-2, Infectious diseases, 【초록키워드】 COVID-19, Treatment, coronavirus disease, neutralizing antibody, Coronavirus disease 2019, Efficacy, coronavirus, pandemic, Mortality, Neutralizing antibodies, antibody, SARS-COV-2 infection, Infection, lung, severe acute respiratory syndrome Coronavirus, hACE2, pathogen, COVID-19 infection, mice, Lungs, Human monoclonal antibody, morbidity, therapeutic, respiratory, in vivo, monoclonal, human monoclonal antibodies, K18-hACE2 transgenic mice, administration, Efficiency, Ablation, life, Severe COVID-19 Infection, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, load, virion, disease symptoms, infective, Administered, approach, sociality, consequence, evaluate, caused, addition, supported, treated, days post infection, exhibit, days post-infection, disease symptom, rescued, preventing infection, 【제목키워드】 Human monoclonal antibody, Neutralizing,