Abstract
The angiotensin-converting enzyme 2(ACE-2) receptors with approx. 0.8% congestion in conjunctival surface, leads to increase susceptibility of Covid-19 transmission through ocular surface. It has been observed that prophylactic measures such as goggle or face shield are unable to offer complete protection against ocular transmission of SRS-CoV-2. Hence, it is hypothesized that topical ocular prophylaxis using biocompatible polymers with reported in-vitro and in-vivo evidence of ACE inhibition and antiviral activity appears to be a promising strategy for preventing ocular transmission of Covid-19 to healthcare workers. They are capable of binding to ACE-2 receptors which may provide highly potential trails to block virus entry to host cells. Further biopolymers imparting antiviral activities greatly improve their protective performance. They not only provide prolong protection but also are safe for long-term use. This article discusses the description of structural and functional attributes of ACE-2 to identify appropriate polymer with better binding affinity. Furthermore, potential polymers with appropriate concentration are suggested for evaluation through a hypothesis to consider them for Covid-19 implication.
Keywords: ACE-2 receptor; Covid-19; Eye infection; Polymer; Virus entry.
【저자키워드】 COVID-19, ACE-2 receptor, Eye infection, Polymer, virus entry, 【초록키워드】 Healthcare workers, susceptibility, Transmission, antiviral activity, binding affinity, Polymer, Prophylaxis, ACE-2, healthcare, virus entry, Face shield, Ocular surface, receptors, receptor, eye, Protective, binding, Angiotensin-converting enzyme, Evidence, Hypothesis, Concentration, angiotensin, ACE, congestion, In-vitro, COVID-19 transmission, Safe, leads, evidence of, host cells, antiviral activities, prophylactic measures, prophylactic measure, description, offer, attribute, conjunctival, ocular, Complete, IMPROVE, identify, reported, functional, appear, suggested, 【제목키워드】 Transmission, SmaRT, ocular,