Abstract At the start of the UK coronavirus disease 2019 epidemic, this rare point prevalence study revealed that one-third of patients (15 of 45) in a London inpatient rehabilitation unit were found to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but asymptomatic. We report on 8 patients in detail, including their clinical stability, the evolution of their nasopharyngeal viral reverse-transcription polymerase chain reaction (RT-PCR) burden, and their antibody levels over time, revealing the infection dynamics by RT-PCR and serology during the acute phase. Notably, a novel serological test for antibodies against the receptor binding domain of SARS-CoV-2 showed that 100% of our asymptomatic cohort remained seropositive 3—6 weeks after diagnosis.
【저자키워드】 COVID-19, SARS-CoV-2, Asymptomatic, anti-RBD, SARS-CoV-2 receptor binding domain (RBD), antibodies to nucleoprotein, anti-NP, Imperial Hybrid DABA, 【초록키워드】 coronavirus disease, Evolution, serological test, Coronavirus disease 2019, coronavirus, serology, antibody, Infection, Diagnosis, rehabilitation, severe acute respiratory syndrome Coronavirus, RT-PCR, Receptor binding domain, polymerase chain reaction, Cohort, Epidemic, stability, Viral, Asymptomatic, Patient, respiratory, London, seropositive, Chain Reaction, point prevalence, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, acute phase, prevalence study, polymerase chain, remained, nasopharyngeal viral, 【제목키워드】 coronavirus 2, response, Presence,