The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin–angiotensin system imbalance in a variety of cell types, primarily endothelial cells. Profound endothelial dysfunction associated with COVID-19 can be the cause of impaired organ perfusion that may generate acute myocardial injury, renal failure, and a procoagulant state resulting in thromboembolic events. We discuss the most recent results on the involvement of endothelial dysfunction in the pathogenesis of COVID-19 in patients with cardiometabolic diseases in this review. We also provide insights on treatments that may reduce the severity of this viral infection.
【저자키워드】 COVID-19, SARS-CoV-2, Pathogenesis, Endothelium, complications, 【초록키워드】 Treatment, coronavirus disease, Apoptosis, viral infection, Coronavirus disease 2019, SARS-CoV2, Pathogenesis, hypoxia, obesity, severity, Diabetes Mellitus, risk, diabetes, virus, hypertension, Endothelial dysfunction, Novel coronavirus, Coronary artery disease, global pandemic, heart failure, Severe acute respiratory syndrome, Consequences, 2019 novel coronavirus, myocardial injury, endothelial cells, Patient, moderate, renal failure, angiotensin, Lower respiratory tract, Coronary artery, cell types, cardiovascular comorbidities, thromboembolic, Thromboembolic events, renin–angiotensin system, problems, cardiometabolic diseases, pathogenesis of COVID-19, upper and lower respiratory tracts, renal, organ, cardiometabolic disease, Affect, hyper inflammation, procoagulant, raise, Non-pulmonary, Organ perfusion, resulting, the patient, generate, variety, cause, reduce, cardiovascular comorbidity, with COVID-19, 【제목키워드】 role,