Paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) (PIMS-TS) is a new systemic inflammatory disease that mainly affects children. Its course in many features resembles that of acute rheumatic fever (ARF). Therefore, it is interesting that the experiences with ARF can be used in the management of patients with PIMS-TS. The aim of the article is to analyse the current data on PIMS-TS in relation to ARF. PIMS-TS and ARF are associated with an abnormal immune response to specific pathogens ( SARS-CoV-2 and group A streptococcus , respectively). The main symptoms of both diseases are fever and cardiac involvement. Current therapy for PIMS-TS is based on anti-inflammatory treatment: intravenous immunoglobulin (first-line), intravenous glucocorticoids (second-line), or biological therapy (third-line; including interleukin [IL]-1 antagonists, IL-6 receptor blockers, and anti-tumour necrosis factor agents). Vaccination might be good prophylaxis, but the efficacy and safety of the vaccines against SARS-CoV-2 have not yet been established in children. Interesting insights may be gained by considering PIMS-TS in light of what is known of ARF due to their similar courses, but there are still many unanswered questions surrounding this disease and its pathogenesis.
【저자키워드】 COVID-19, paediatric inflammatory multisystemic syndrome (PIMS), rheumatic fever, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, Necrosis, Glucocorticoids, Intravenous immunoglobulin, coronavirus, therapy, Pathogenesis, Anti-inflammatory, IL-6, children, Symptom, severe acute respiratory syndrome Coronavirus, glucocorticoid, Prophylaxis, interleukin, pathogen, Immunoglobulin, management, paediatric inflammatory multisystem syndrome, Fever, Patient, Pathogens, Efficacy and safety, disease, PIMS, Inflammatory, anti-inflammatory treatment, rheumatic fever, intravenous, IL-6 receptor, acute respiratory syndrome, acute respiratory syndrome coronavirus, syndrome, antagonists, article, blockers, inflammatory disease, current therapy, courses, Affect, feature, acute rheumatic fever, current, abnormal immune response, systemic inflammatory, Course, can be used, question, the vaccine, ARF, 【제목키워드】 SARS-CoV-2, systemic, exposure to, New,