We report of two cases of progressed COVID-19 with negative PCR tests from nasopharyngeal swabs, in whom diagnosis was made by different antibody assays, including a lateral flow rapid test and multiple commercial ELISAs, finally confirmed by comprehensive serological assays. These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation. Electronic supplementary material The online version of this article (10.1007/s15010-020-01497-2) contains supplementary material, which is available to authorized users.
【저자키워드】 antibodies, coronavirus, SARS, immunoassay, Rapid test, PCR negative, 【초록키워드】 COVID-19, Diagnosis, ELISA, lateral flow, Seroconversion, Serological assay, Rapid test, serological assays, nasopharyngeal swabs, serological, ELISAs, Rapid tests, Antibody assays, Combination, PCR tests, supplementary material, confirmation, severely ill patients, highlight, negative PCR tests, significantly, question, diagnosis of COVID-19, negative PCR test, progressed, severely ill patient, 【제목키워드】 COVID-19, Nasopharyngeal swab, antibody assay, Negative PCR,