Abstract The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide pandemic. Disseminated lung injury with the development of acute respiratory distress syndrome (ARDS) is the main cause of mortality in COVID‐19. Although liver failure does not seem to occur in the absence of pre‐existing liver disease, hepatic involvement in COVID‐19 may correlate with overall disease severity and serve as a prognostic factor for the development of ARDS. The spectrum of liver injury in COVID‐19 may range from direct infection by SARS‐CoV‐2, indirect involvement by systemic inflammation, hypoxic changes, iatrogenic causes such as drugs and ventilation to exacerbation of underlying liver disease. This concise review discusses the potential pathophysiological mechanisms for SARS‐CoV‐2 hepatic tropism as well as acute and possibly long‐term liver injury in COVID‐19.
【초록키워드】 coronavirus disease, Coronavirus disease 2019, ARDS, pandemic, Mortality, acute respiratory distress syndrome, disease severity, Ventilation, drug, Lung injury, severe acute respiratory syndrome Coronavirus, COVID‐19, SARS‐CoV‐2, outbreak, Liver injury, systemic inflammation, respiratory, Spectrum, liver, acute respiratory distress, Liver disease, Prognostic factor, liver failure, respiratory distress, changes, Exacerbation, acute respiratory syndrome coronavirus, syndrome, pathophysiological mechanism, direct infection, hypoxic, caused, absence, occur, cause, iatrogenic, 【제목키워드】 COVID‐19, mechanism,