Background Coronavirus disease 2019 (COVID-19) induces myocardial injury, either direct myocarditis or indirect injury due to systemic inflammatory response. Myocardial involvement has been proved to be one of the primary manifestations of COVID-19 infection, according to laboratory test, autopsy, and cardiovascular magnetic resonance (CMR). However, the middle-term outcome of cardiac involvement after the patients were discharged from the hospital is yet unknown. The present study aimed to evaluate mid-term cardiac sequelae in recovered COVID-19 patients by CMR Methods A total of 47 recovered COVID-19 patients were prospectively recruited and underwent CMR examination. The CMR protocol consisted of black blood fat-suppressed T2 weighted imaging, T2 star mapping, left ventricle (LV) cine imaging, pre- and post-contrast T1 mapping, and late gadolinium enhancement (LGE). LGE were assessed in mixed both recovered COVID-19 patients and healthy controls. The LV and right ventricle (RV) function and LV mass were assessed and compared with healthy controls. Results A total of 44 recovered COVID-19 patients and 31 healthy controls were studied. LGE was found in 13 (30%) of COVID-19 patients. All LGE lesions were located in the mid myocardium and/or sub-epicardium with a scattered distribution. Further analysis showed that LGE-positive patients had significantly decreased LV peak global circumferential strain (GCS), RV peak GCS, RV peak global longitudinal strain (GLS) as compared to non-LGE patients ( p < 0.05), while no difference was found between the non-LGE patients and healthy controls. Conclusion Myocardium injury existed in 30% of COVID-19 patients. These patients have depressed LV GCS and peak RV strains at the 3-month follow-up. CMR can monitor the COVID-19-induced myocarditis progression, and CMR strain analysis is a sensitive tool to evaluate the recovery of LV and RV dysfunction.
【저자키워드】 COVID-19, Cardiac magnetic resonance imaging, cardiac dysfunction, cardiac involvement, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, protocol, hospital, progression, outcome, Autopsy, Laboratory, myocardial injury, COVID-19 infection, myocarditis, Patient, Follow-up, distribution, COVID-19 patients, Blood, Recovered COVID-19 patients, Analysis, right ventricle, Injury, strain, manifestation, GLS, Laboratory test, gadolinium, lesion, Myocardium, left ventricle, healthy control, no difference, systemic inflammatory response, healthy controls, STAR, RV dysfunction, MONITOR, myocardial involvement, recovered COVID-19 patient, epicardium, Result, evaluate, significantly, recruited, the patient, induce, discharged, were assessed, 【제목키워드】 cardiac,