Abstract
There has been a growing and evolving research to find a treatment or a prevention against coronavirus 2019 (COVID-19). Though mass vaccination will certainly help in reducing number of COVID-19 patients, an effective therapeutic measure must be available too. Intravenous remdesivir (RDV) was the first drug receiving Food and Drug Administration (FDA) approval for the treatment of COVID-19. However, in a pandemic like COVID-19, it is essential that drug formulations are readily available, affordable and convenient to administer to every patient around the globe. In this study, we have developed a Self-injectable extended release subcutaneous injection of Remdesivir (SelfExRem) for the treatment of COVID-19. As opposed to intravenous injection, extended release subcutaneous injection has the benefits of reducing face-to-face contact, minimizing hospitalization, reducing dosing frequency and reducing overall health care cost. SelfExRem was developed using a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), dissolved in a biocompatible vehicle. Six different batches were formulated using 2 different grades of low molecular weight PLGA and 3 different PLGA concentration. The force of injection of various polymeric solutions through 23-30-gauge needles were analyzed using a TA.XTplus texture analyzer. The time required for injection was evaluated both manually and by using an autoinjector. In vitro release of all the batches were carried out in 1% v/v tween 80 in phosphate buffer saline. The study indicated that SelfExRem developed with15% w/v PLGA(75:25) provided a steady release of drug for 48 h and may be a breakthrough approach for the treatment of COVID-19.
Keywords: Covid19; In situ depot formulations; Long-acting injectables; Remdesivir; SARS-CoV2.
【저자키워드】 SARS-CoV2, COVID19, Remdesivir, In situ depot formulations, Long-acting injectables, 【초록키워드】 COVID-19, Treatment, coronavirus, SARS-CoV2, vaccination, pandemic, Health care, Hospitalization, Remdesivir, drug, FDA, Polymer, Health, therapeutic, Research, Patient, Coronavirus 2019, Care, COVID-19 patients, RDV, food, Frequency, Concentration, low molecular weight, mass vaccination, phosphate, subcutaneous injection, Intravenous injection, biodegradable polymer, treatment of COVID-19, help, approval, injection, Drug administration, PLGA, autoinjector, force, Intravenous remdesivir, tween, approach, effective, benefit, face-to-face contact, phosphate buffer, analyzed, carried, globe, indicated, evaluated, required, provided, receiving, reducing, administer, w/v, 【제목키워드】 COVID-19, Treatment, Remdesivir,