Background Vertical transmission of coronavirus disease 2019 (COVID-19) from mother to newborn infant is doubtful, and very little is known about disease severity and neonatal outcome. Case presentation We present a preterm Iranian infant born to a Persian mother with severe COVID-19 pneumonia. The mother underwent cesarean delivery, and amniotic fluid yielded a positive result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR). The newborn infant showed early-onset infection with SARS-CoV-2 confirmed on pharyngeal swabs by RT-PCR assay within 24 hours after birth, suggesting vertical transmission. Unfortunately, the mother died 14 days after delivery. We describe the clinical course and outcome of the infant up to 7 months of age. Conclusion COVID-19 infection in pregnant women may increase maternal morbidity, mortality and possibly vertical transmission in severe cases. However, it does not seem to progress to serious early or late neonatal complications.
【저자키워드】 COVID-19, SARS-CoV-2, Neonate, vertical transmission, Preterm infant, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Severe COVID-19 pneumonia, coronavirus, COVID-19 pneumonia, Mortality, disease severity, Transmission, outcome, severe acute respiratory syndrome Coronavirus, RT-PCR, Infant, pregnant women, reverse transcription polymerase chain reaction, polymerase chain reaction, Clinical course, COVID-19 infection, morbidity, Amniotic fluid, Birth, severe cases, complications, vertical transmission, age, reverse transcription, RT-PCR assay, mother, Neonatal, 24 hours, Chain Reaction, Pharyngeal swab, Real-Time Reverse Transcription Polymerase Chain Reaction, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, positive result, PCR assay, early-onset, polymerase chain, newborn infant, died, 24 hour, amniotic, infection with SARS-CoV-2, 【제목키워드】 severe COVID-19, Transmission, outcome, Case report, clinical, vertical transmission, radiological finding, Course,