Currently, treating coronavirus disease 2019 (COVID19) patients, particularly those afflicted with severe pneumonia, is challenging, as no effective pharmacotherapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists. Severe pneumonia is recognized as a clinical syndrome, characterized by hyper induction of proinflammatory cytokine production, which can induce organ damage followed by edema, dysfunction of air exchange, acute respiratory distress syndrome, acute cardiac injury, secondary infection, and increased mortality. Owing to the immunoregulatory and differentiation potential of mesenchymal stem cells (MSCs), we aimed to outline current insights into the clinical application of MSCs in the patients of COVID19. Based on results from preliminary clinical investigations, one predicts that MSCs therapy for SARS-CoV-2 infected patients is safe and effective although multiple clinical trials with a protracted follow-up will be necessary to determine the long term effects of the treatment on COVID19 patients.
【저자키워드】 SARS-CoV-2, Cytokine storm, coronavirus, COVID19, Pneumonia, immunomodulation, Mesenchymal stem cells, CRP, C-reactive protein, ALT, alanine aminotransferase, AST, aspartate aminotransferase, TNF-α, tumor necrosis factor alpha, VEGF, Vascular endothelial growth factor, RT-PCR, Reverse transcription polymerase chain reaction, IFN-γ, interferon gamma, IL-1β, interleukin 1 beta, MHC-I, major histocompatibility complex class I, MHC-II, major histocompatibility complex class II, MCP-1, monocyte chemoattractant protein 1, LPS, lipopolysaccharide, GCSF, granulocyte colony stimulating factor, PDGF, platelet derived growth factor, IL-2, interleukin 2, IL-6, interleukin 6, IL-10, interleukin 10, Fio2, fraction of inspired oxygen, Pao2, partial pressure of oxygen, IL-7, interleukin 7, Ang-1, Angiopoietin 1, MIP-1α, Macrophage Inflammatory Proteins 1 alpha, ICAM, Intercellular Adhesion Molecule 1, VCAM, Vascular Cell Adhesion Protein 1, BDNF, Brain Derived Neurotrophic factor, TLR3, Toll like Receptors 3, TLR4, Toll like Receptors 4, PCT, Proximal Convoluted Tubule, SAA, Specialized Adoption Agency, PSI, Pound per Square Inch, CT Scan, Computerized Tomography Scan,