The COVID-19 global epidemic caused by coronavirus has affected the health and other aspects of life for more than one year. Despite the current pharmacotherapies, there is still no specific treatment, and studies are in progress to find a proper therapy with high efficacy and low side effects. In this way, Traditional Persian Medicine (TPM), due to its holistic view, can provide recommendations for the prevention and treatment of new diseases such as COVID-19. The muco-obstruction of the airway, which occurs in SARS-CoV-2, has similar features in TPM textbooks that can lead us to new treatment approaches. Based on TPM and pharmacological studies, Cinnamomum verum (Darchini)’s potential effective functions can contribute to SARS-CoV-2 infection treatment and has been known to be effective in corona disease in Public beliefs. From the viewpoint of TPM theories, Cinnamon can be effective in SARS-CoV-2 improvement and treatment through its anti-obstructive, diuretic, tonic and antidote effects. In addition, there is pharmacological evidence on anti-viral, anti-inflammatory, antioxidant, organ-o-protective and anti-depression effects of Cinnamon that are in line with the therapeutic functions mentioned in TPM.Overall, Cinnamon and its ingredients can be recommended for SARS-CoV2 management due to multi-targeting therapies. This review provides basic information for future studies on this drug’s effectiveness in preventing and treating COVID-19 and similar diseases. Graphical Abstract ga1
【저자키워드】 COVID-19, COVID-19, Coronavirus disease 2019, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, ACE2, angiotensin-converting enzyme 2, COPD, Chronic obstructive pulmonary disease, TMPRSS2, Transmembrane serine protease 2, ARDS, acute respiratory distress syndrome, IL, interleukin, ICU, Intensive care unit, ALT, alanine aminotransferase, AST, aspartate aminotransferase, LDH, lactate dehydrogenase, obstruction, GPX, glutathione peroxidase, ROS, reactive oxygen species, ERK, extracellular signal-regulated kinases, COX-2, cyclooxygenase-2, LPS, lipopolysaccharides, iNOS, nitric oxide synthase, BAL, bronchoalveolar lavage, IFN-γ, interferon-γ, TNF-α, tumor necrosis factor-α, cinnamon, TLRs, Toll-like receptors, BUN, blood urea nitrogen, MCP-1, monocyte Chemoattractant Protein-1, TC, total cholesterol, GSH, glutathione, SOD, Superoxide dismutase, LDL, low-density lipoprotein, PCNA, proliferating cell nuclear antigen, NAFLD, non-alcoholic fatty liver disease, MDA, malondialdehyde, VCAM-1, Vascular cell adhesion molecule-1, TPM, Traditional Persian Medicine, TCA, Trans-cinnamaldehyde, p38 MAPK, p38 mitogen-activated protein kinases, JNK, Jun N-terminal kinases, BHT, butylated hydroxytoluene, CAT, catalase, EEC, Ethanolic extract of Cinnamon, QR, quinone reductase, γ-GCS, gamma-glutamylcysteine synthetase, TAPP, Type-A procyanidine polyphenols, CK-MB, creatine kinase-MB, ATI, acute tubule injury, PCB2, procyanidin-B2, PKC-a, protein kinase C-a, TBARS, thiobarbituric acid reactive substances, PCO, protein carbonyl, HOMA, Homeostatic Model Assessment, FBS, fasting blood glucose, TG, Triglycerides, GGT, gamma glutamine transpeptidase, BCP, β-Caryophyllene,