[키워드]
ARDS, acute respiratory distress syndrome
CAR, Chimeric antigen receptor
COPD, Chronic obstructive pulmonary disease
COVID-19
COVID-19, Coronavirus disease 2019
CRP, C-reactive protein
FiO2, fraction of inspired oxygen
IL-6
IL-6R, IL-6 receptor
IMV, invasive mechanical ventilation
Invasive mechanical ventilation
IQR, interquartile range
LDH, lactate dehydrogenase
PaO2, Arterial oxygen tension
ROC, Receiver-operating characteristic
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
TCZ, tocilizumab
Tocilizumab
[저자] José María Galván-Román, Sebastián C. Rodríguez-García, Emilia Roy-Vallejo, Ana Marcos-Jiménez, Santiago Sánchez-Alonso, Carlos Fernández-Díaz, Ana Alcaraz-Serna, Tamara Mateu-Albero, Pablo Rodríguez-Cortes, Ildefonso Sánchez-Cerrillo, Laura Esparcia, Pedro Martínez-Fleta, Celia López-Sanz, Ligia Gabrie, Luciana del Campo Guerola, Carmen Suárez-Fernández, Julio Ancochea, Alfonso Canabal, Patricia Albert, Diego A. Rodríguez-Serrano, Juan Mariano Aguilar, Carmen del Arco, Ignacio de los Santos, Lucio García-Fraile, Rafael de la Cámara, José María Serra, Esther Ramírez, Tamara Alonso, Pedro Landete, Joan B. Soriano, Enrique Martín-Gayo, Arturo Fraile Torres, Nelly Daniela Zurita Cruz, Rosario García-Vicuña, Laura Cardeñoso, Francisco Sánchez-Madrid, Arantzazu Alfranca, Cecilia Muñoz-Calleja, Isidoro González-Álvaro,
REINMUN-COVID Group§AlvaradoTeresaMartínezPabloJavier de la Cuerda LlorenteFranciscoArcoCarmen delAguilarJuan MarianoVillalbaNataliaNegroMónicaContrerasElviraReyAna delSantiagoCristinaJunqueraManuelCamineroRaquelValFrancisco JavierGonzálezSoniaCañoMartaLópezIsabelvon WernitzAndrésRetanaBárbaraGuerraIñigoSorandoJorgeChaoLydiaCárdenasMaría JoséEspigaVerónicaChicharroPabloRodríguezPedroAldayIñigo HernandoSampedroMiguelPradaJorgeAldamaEukene RojoRealYolandaCaldasMaríaCasabonaSergioLanas-GimenoAitorCamaraRafael de laAlvárezAngela FigueraAguadolBeatrizMorellAlbertoRamírezEstherZurriagaAmparo IbáñezAbanadesMaría PérezGarcíaSilvia RuizArandaTomás GallegoRuizMaríaNietoConcepción MartínezSerraJosé MaríaSánchez-MadridFranciscoMuñoz-CallejaCeciliaAlfrancaArantzazuAspaJavierMarcos-JiménezAnaSánchez-AlonsoSantiagoAlcaraz-SernaAnaMateu-AlberoTamaraSánchez-CerrilloIldefonsoEsparciaLauraMartínez-FletaPedroLópez-SanzCeliaGabrieLigiaGuerolaLuciana del CampoFernándezElenaCalzadaMa JoséTejedorReyesCanabalAlfonsoAlbertPatriciaRodríguez-SerranoDiego A.IglesiasJuditSuarezFernandoSánchezJuan AntonioAbadBeatrizSuarezCarmenSantosIgnacio de losGalván-RománJosé MaríaRoyEmiliaRodríguez-CortesPabloGarcía-FraileLucioSanzJesusSanchezEduardoMoldenhauerFernandoCasadoPedroCurbeloJoseGutierrezAngelaBautistaAzucenaGiménezNuria RuizFernandezAngelicaParraPedroMoyanoBertaBarriosAnaReal de AsuaDiegoSanchezBeatrizSaezCarmenCiudadMarianelaNavasDesiréDomingoLaura CardeñosoTorresanoMaría del Carmen CuevasGarcíaDiego DomingoCaveroTeresa AlarcónBlancoAlicia GarcíaRamírezAlexandra MartínSemiglia ChongMaría AuxiliadoraCobosAinhoa GutiérrezZurita CruzNelly DanielaFraile TorresArturo ManuelSanchez-GonzalezCarmenPerpénAntonio FernádezPérezCarolina DíazAncocheaJulioAlonsoTamaraLandetePedroSorianoJoanCisnerosCarolinaCastilloElena GarcíaGarcía PérezFrancisco JavierGirónRosa MaríaMarcosCelesteZamoraEnriqueGarcíaPatricia GarcíaCastañedaSantosGarcía-VicuñaRosarioGonzález-ÁlvaroIsidoroRodríguez-GarcíaSebastiánFernández-DíazCarlosCubasIrene LlorenteTomeroEva G.CastañedaNoelia GarcíaOrtizAna MaValeroCristinaUriarteMirenMontesNuria
, Teresa Alvarado, Pablo Martínez, Francisco Javier de la Cuerda Llorente, Carmen del Arco, Juan Mariano Aguilar, Natalia Villalba, Mónica Negro, Elvira Contreras, Ana del Rey, Cristina Santiago, Manuel Junquera, Raquel Caminero, Francisco Javier Val, Sonia González, Marta Caño, Isabel López, Andrés von Wernitz, Bárbara Retana, Iñigo Guerra, Jorge Sorando, Lydia Chao, María José Cárdenas, Verónica Espiga, Pablo Chicharro, Pedro Rodríguez, Iñigo Hernando Alday, Miguel Sampedro, Jorge Prada, Eukene Rojo Aldama, Yolanda Real, María Caldas, Sergio Casabona, Aitor Lanas-Gimeno, Rafael de la Camara, Angela Figuera Alvárez, Beatriz Aguadol, Alberto Morell, Esther Ramírez, Amparo Ibáñez Zurriaga, María Pérez Abanades, Silvia Ruiz García, Tomás Gallego Aranda, María Ruiz, Concepción Martínez Nieto, José María Serra, Francisco Sánchez-Madrid, Cecilia Muñoz-Calleja, Arantzazu Alfranca, Javier Aspa, Ana Marcos-Jiménez, Santiago Sánchez-Alonso, Ana Alcaraz-Serna, Tamara Mateu-Albero, Ildefonso Sánchez-Cerrillo, Laura Esparcia, Pedro Martínez-Fleta, Celia López-Sanz, Ligia Gabrie, Luciana del Campo Guerola, Elena Fernández, M Calzada, Reyes Tejedor, Alfonso Canabal, Patricia Albert, Diego A. Rodríguez-Serrano, Judit Iglesias, Fernando Suarez, Juan Antonio Sánchez, Beatriz Abad, Carmen Suarez, Ignacio de los Santos, José María Galván-Román, Emilia Roy, Pablo Rodríguez-Cortes, Lucio García-Fraile, Jesus Sanz, Eduardo Sanchez, Fernando Moldenhauer, Pedro Casado, Jose Curbelo, Angela Gutierrez, Azucena Bautista, Nuria Ruiz Giménez, Angelica Fernandez, Pedro Parra, Berta Moyano, Ana Barrios, Diego Real de Asua, Beatriz Sanchez, Carmen Saez, Marianela Ciudad, Desiré Navas, Laura Cardeñoso Domingo, María del Carmen Cuevas Torresano, Diego Domingo García, Teresa Alarcón Cavero, Alicia García Blanco, Alexandra Martín Ramírez, María Auxiliadora Semiglia Chong, Ainhoa Gutiérrez Cobos, Nelly Daniela Zurita Cruz, Arturo Manuel Fraile Torres, Carmen Sanchez-Gonzalez, Antonio Fernádez Perpén, Carolina Díaz Pérez, Julio Ancochea, Tamara Alonso, Pedro Landete, Joan Soriano, Carolina Cisneros, Elena García Castillo, Francisco Javier García Pérez, Rosa María Girón, Celeste Marcos, Enrique Zamora, Patricia García García, Santos Castañeda, Rosario García-Vicuña, Isidoro González-Álvaro, Sebastián Rodríguez-García, Carlos Fernández-Díaz, Irene Llorente Cubas, Eva G. Tomero, Noelia García Castañeda, Ana M Ortiz, Cristina Valero, Miren Uriarte, Nuria Montes
[Category] SARS,
[Article Type] Clinical Trial
[Source] PMC
Background Patients with coronavirus disaese 2019 (COVID-19) can develop a cytokine release syndrome that eventually leads to acute respiratory distress syndrome requiring invasive mechanical ventilation (IMV). Because IL-6 is a relevant cytokine in acute respiratory distress syndrome, the blockade of its receptor with tocilizumab (TCZ) could reduce mortality and/or morbidity in severe COVID-19. Objective We sought to determine whether baseline IL-6 serum levels can predict the need for IMV and the response to TCZ. Methods A retrospective observational study was performed in hospitalized patients diagnosed with COVID-19. Clinical information and laboratory findings, including IL-6 levels, were collected approximately 3 and 9 days after admission to be matched with preadministration and postadministration of TCZ. Multivariable logistic and linear regressions and survival analysis were performed depending on outcomes: need for IMV, evolution of arterial oxygen tension/fraction of inspired oxygen ratio, or mortality. Results One hundred forty-six patients were studied, predominantly males (66%); median age was 63 years. Forty-four patients (30%) required IMV, and 58 patients (40%) received treatment with TCZ. IL-6 levels greater than 30 pg/mL was the best predictor for IMV (odds ratio, 7.1; P < .001). Early administration of TCZ was associated with improvement in oxygenation (arterial oxygen tension/fraction of inspired oxygen ratio) in patients with high IL-6 ( P = .048). Patients with high IL-6 not treated with TCZ showed high mortality (hazard ratio, 4.6; P = .003), as well as those with low IL-6 treated with TCZ (hazard ratio, 3.6; P = .016). No relevant serious adverse events were observed in TCZ-treated patients. Conclusions Baseline IL-6 greater than 30 pg/mL predicts IMV requirement in patients with COVID-19 and contributes to establish an adequate indication for TCZ administration.
All Keywords
【저자키워드】 COVID-19, Tocilizumab, IL-6, COVID-19, Coronavirus disease 2019, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, COPD, Chronic obstructive pulmonary disease, ARDS, acute respiratory distress syndrome, Invasive mechanical ventilation, IQR, interquartile range, CRP, C-reactive protein, LDH, lactate dehydrogenase, CAR, Chimeric antigen receptor, FiO2, fraction of inspired oxygen, IMV, invasive mechanical ventilation, TCZ, tocilizumab, IL-6R, IL-6 receptor, ROC, Receiver-operating characteristic, PaO2, Arterial oxygen tension,