Purpose To evaluate the efficacy and safety of lung low-dose radiation therapy (LD-RT) for pneumonia in patients with coronavirus disease 2019 (COVID-19). Materials and methods Inclusion criteria comprised patients with COVID-19-related moderate–severe pneumonia warranting hospitalization with supplemental O 2 and not candidates for admission to the intensive care unit because of comorbidities or general status. All patients received single lung dose of 0.5 Gy. Respiratory and systemic inflammatory parameters were evaluated before irradiation, at 24 h and 1 week after LD-RT. Primary endpoint was increased in the ratio of arterial oxygen partial pressure (PaO 2 ) or the pulse oximetry saturation (SpO 2 ) to fractional inspired oxygen (FiO 2 ) ratio of at least 20% at 24 h with respect to the preirradiation value. Results Between June and November 2020, 36 patients with COVID-19 pneumonia and a mean age of 84 years were enrolled. Seventeen were women and 19 were men and all of them had comorbidities. All patients had bilateral pulmonary infiltrates on chest X‑ray. All patients received dexamethasone treatment. Mean SpO 2 pretreatment value was 94.28% and the SpO 2 /FiO 2 ratio varied from 255 mm Hg to 283 mm Hg at 24 h and to 381 mm Hg at 1 week, respectively. In those who survived (23/36, 64%), a significant improvement was observed in the percentage of lung involvement in the CT scan at 1 week after LD-RT. No adverse effects related to radiation treatment have been reported. Conclusions LD-RT appears to be a feasible and safe option in a population with COVID-19 bilateral interstitial pneumonia in the presence of significant comorbidities. Supplementary Information The online version of this article (10.1007/s00066-021-01803-3) contains supplementary material, which is available to authorized users.
【저자키워드】 COVID-19 pneumonia, Low-dose radiation therapy, Treatment outcome, Anti-inflammatory effects, Lung irradiation, 【초록키워드】 COVID-19, Dexamethasone, Treatment, coronavirus disease, Coronavirus disease 2019, COVID-19 pneumonia, intensive care, Hospitalization, Pneumonia, pulse oximetry, lung involvement, Comorbidities, intensive care unit, lung, Comorbidity, oxygen, adverse effects, low-dose, CT scan, Chest, Patient, age, Efficacy and safety, women, interstitial pneumonia, respiratory, Admission, radiation therapy, primary endpoint, dose, Safe, criteria, partial pressure, oxygen partial pressure, radiation treatment, Radiation, adverse effect, Endpoint, supplementary material, arterial oxygen partial pressure, bilateral pulmonary infiltrates, fractional inspired oxygen, irradiation, candidate, material, parameter, men, systemic inflammatory, Result, enrolled, evaluate, reported, evaluated, appear, bilateral pulmonary infiltrate, PaO, those who survived, was increased, with COVID-19, 【제목키워드】 Treatment, Trial, multicenter, Prospective trial, nonrandomized, patients with COVID-19,