Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200 mL of CCP with a spike protein IgG titer ≥ 1:2430 (median 1:47,385) within 72 hours of admission with propensity score–matched controls cared for at a medical center in the Bronx, between April 13 and May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroid use, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared with matched controls, CCP recipients less than 65 years had 4-fold lower risk of mortality and 4-fold lower risk of deterioration in oxygenation or mortality at day 28. For CCP recipients, pretransfusion spike protein IgG, IgM, and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients less than 65 years, but data from controlled trials are needed to validate this finding and establish the effect of aging on CCP efficacy.
【저자키워드】 COVID-19, immunoglobulins, Infectious disease, 【초록키워드】 Corticosteroid, Treatment, coronavirus disease, convalescent plasma, SARS-CoV-2, IgG, IgM, Coronavirus disease 2019, Efficacy, coronavirus, Mortality, anticoagulation, antibody, aging, Comorbidities, Sex, D-dimer, oxygen, hospitalized patients, Spike protein, Clinical outcome, lymphocyte, Ethnicity, Deterioration, body mass index, controlled trials, Controlled trial, Control, plasma, age, Admission, Propensity score, acute respiratory disease, Oxygenation, criteria, CCP, body mass, adverse effect, recipients, no difference, lower risk, promise, lymphocyte counts, recipient, Oxygen requirement, matching, IgA titers, controls, median, less, hospitalized patient, analyses, stratified, IgA titer, patients with COVID-19, 【제목키워드】 severe COVID-19,