Abstract Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
All Keywords
【저자키워드】 COVID-19, Neutrophil extracellular traps, immunothrombosis, fostamatinib,
【저자키워드】 COVID-19, Neutrophil extracellular traps, immunothrombosis, fostamatinib,