Inflammasomes are intracellular protein complexes that form in response to a variety of stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1β and pro-interleukin-18 to active interleukin-1β and interleukin-18, central mediators of the inflammatory response; inflammasomes can also promote a type of cell death known as pyroptosis. The NLRP3 inflammasome has received the most study and plays an important pathogenic role in a vast range of pathologies associated with inflammation—including atherosclerosis, myocardial infarction, the complications of diabetes, neurological and autoimmune disorders, dry macular degeneration, gout, and the cytokine storm phase of COVID-19. A consideration of the molecular biology underlying inflammasome priming and activation enables the prediction that a range of nutraceuticals may have clinical potential for suppressing inflammasome activity—antioxidants including phycocyanobilin, phase 2 inducers, melatonin, and N-acetylcysteine, the AMPK activator berberine, glucosamine, zinc, and various nutraceuticals that support generation of hydrogen sulfide. Complex nutraceuticals or functional foods featuring a number of these agents may find utility in the prevention and control of a wide range of medical disorders.
【저자키워드】 COVID-19, Zinc, N-acetylcysteine, NLRP3, inflammasomes, phycocyanobilin, lipoic acid, ferulic acid, berberine, glucosamine, macular degeneration, 【초록키워드】 pathology, Molecular biology, melatonin, Stress, diabetes, NLRP3 inflammasome, AMPK, Atherosclerosis, pyroptosis, Complication, Inflammasome, nutraceutical, Myocardial infarction, cell death, utility, Gout, interleukin-1β, Inflammatory, Autoimmune disorders, neurological, Hydrogen sulfide, Support, Activation, disorders, priming, pathogenic, protein complex, functional, variety, promote, proteolytic, the cytokine storm, 【제목키워드】 Strategy, nutraceutical, Suppressing,