Introduction Immunoglobulins (Igs) comprise a critical part of the immune response. Little information exists on Ig serum levels in COVID-19 patients. We, therefore, investigated whether hospital admission Igs in patients with mild-to-critical disease are associated with clinical outcome. Materials and Methods This prospective, observational, single-center, cross-sectional study included 126 consecutive non-critically ill and critically ill and COVID-19 patients, in whom IgG, IgM, and IgA were measured on hospital admission. Results The cohort was divided in survivors and non-survivors, based on in-hospital mortality. Median IgG levels of survivors were significantly higher than non-survivors ( p < 0.01). The cohort was subsequently divided in IgG deficient (< 690 mg/dl) and sufficient (≥ 690 mg/dl) patients. IgG-deficient patients had a higher mortality rate ( p < 0.01). The multivariate logistic regression model showed that subnormal IgG was significantly associated with increased mortality risk ( p < 0.01). Conclusion In our COVID-19 cohort, admission subnormal IgG levels might be independently associated with reduced survival.
【저자키워드】 COVID-19, Mortality, intensive care unit, Immunoglobulin G, 【초록키워드】 IgG, IgM, immune response, cross-sectional, risk, Clinical outcome, Cohort, survival, Critically ill, IgA, Patient, Hospital admission, mortality rate, information, disease, Admission, Critical, patients, in-hospital mortality, COVID-19 patients, Non-survivors, Serum level, multivariate logistic regression, single-center, increased mortality, material, survivor, COVID-19 cohort, non-survivor, Result, significantly, investigated, reduced, significantly higher, were measured, IgG deficient, IgG level, 【제목키워드】 Immunoglobulin G, Prospective, Level, Poor,