Summary Introduction Since the declaration of COVID-19 by the World Health Organisation (WHO) as a global pandemic on 11th March 2020, the number of deaths continue to increase worldwide. Reports on its pathologic manifestations have been published with very few from the Sub-Saharan African region. This article reports autopsies on COVID-19 patients from the Ga-East and the 37 Military Hospitals to provide pathological evidence for better understanding of COVID-19 in Ghana. Methods Under conditions required for carrying out autopsies on bodies infected with category three infectious agents, with few modifications, complete autopsies were performed on twenty patients with ante-mortem and/or postmortem RT -PCR confirmed positive COVID-19 results, between April and June, 2020. Results There were equal proportion of males and females. Thirteen (65%) of the patients were 55years or older with the same percentage (65%) having Type II diabetes and/or hypertension. The most significant pathological feature found at autopsy was diffuse alveolar damage. Seventy per cent (14/20) had associated thromboemboli in the lungs, kidneys and the heart. Forty per cent (6/15) of the patients that had negative results for COVID-19 by the nasopharyngeal swab test before death had positive results during postmortem using bronchopulmonary specimen. At autopsy all patients were identified to have pre-existing medical conditions. Conclusion Diffuse alveolar damage was a key pathological feature of deaths caused by COVID-19 in all cases studied with hypertension and diabetes mellitus being major risk factors. Individuals without co-morbidities were less likely to die or suffer severe disease from SARS-CoV-2 Funding None declared
【저자키워드】 COVID-19, Autopsy, Ghana, Diffuse alveolar damage, thromboemboli, 【초록키워드】 SARS-CoV-2, Risk factors, Diabetes Mellitus, hypertension, kidney, global pandemic, African, Lungs, male, Patient, death, co-morbidity, WHO, funding, Evidence, severe disease, COVID-19 patient, Medical conditions, manifestation, infectious agents, alveolar damage, Older, individual, positive result, specimen, World Health Organisation, modifications, report, diffuse, positive COVID-19, nasopharyngeal swab test, Complete, females, Result, performed, caused, proportion, pathologic, the patient, required, condition, less, Type, diabete, RT -PCR,