We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E and OC43 in 11 SARS-CoV-2 serodiscordant couples in Strasbourg, France, in which 1 partner had evidence of mild coronavirus disease (COVID-19) and in 10 unexposed healthy controls. Patients with confirmed COVID-19 were considered index patients and their partners close contacts. All index patients displayed positive SARS-CoV-2–specific antibody and T-cell responses that lasted up to 102 days after symptom onset. All contacts remained seronegative for SARS-CoV-2; however, 6 reported COVID-19 symptoms within a median of 7 days after their partners, and 4 of those showed a positive SARS-CoV-2–specific T-cell response against 3 or 4 SARS-CoV-2 antigens that lasted up to 93 days after symptom onset. The 11 couples and controls displayed positive T-cell responses against HCoV-229E or HCoV-OC43. These data suggest that exposure to SARS-CoV-2 can induce virus-specific T-cell responses without seroconversion.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, antibodies, SARS-CoV-2, IgG, IgM, interferon, RT-PCR, IgA, serologic testing, coronavirus symptoms, household exposure, intrafamilial contacts, viral-specific T-cell response, 【초록키워드】 coronavirus, antibody, T-cell Response, HCoV-OC43, Seroconversion, Patient, Control, France, Mild, HCoV-229E, SARS-CoV-2 antigen, seronegative, OC43, 229E, Evidence, Contact, COVID-19 symptom, symptom onset, acute respiratory syndrome, healthy controls, positive, reported, investigated, remained, median, induce, SARS-CoV-2–specific antibody, virus-specific T-cell response, 【제목키워드】 response, France, exposure to,