Abstract Background Few studies have assessed the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Africa. We report findings from a survey among HCWs in 3 counties in Kenya. Methods We recruited 684 HCWs from Kilifi (rural), Busia (rural), and Nairobi (urban) counties. The serosurvey was conducted between 30 July and 4 December 2020. We tested for immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay. Assay sensitivity and specificity were 92.7 (95% CI, 87.9-96.1) and 99.0% (95% CI, 98.1-99.5), respectively. We adjusted prevalence estimates, using bayesian modeling to account for assay performance. Results The crude overall seroprevalence was 19.7% (135 of 684). After adjustment for assay performance, seroprevalence was 20.8% (95% credible interval, 17.5%–24.4%). Seroprevalence varied significantly ( P < .001) by site: 43.8% (95% credible interval, 35.8%–52.2%) in Nairobi, 12.6% (8.8%–17.1%) in Busia and 11.5% (7.2%–17.6%) in Kilifi. In a multivariable model controlling for age, sex, and site, professional cadre was not associated with differences in seroprevalence. Conclusion These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre. In this study of antibodies to severe acute respiratory syndrome coronavirus 2 among healthcare workers in 3 counties in Kenya, we found significant regional differences in seroprevalence but no differences according to professional cadre.
【저자키워드】 antibodies, SARS-CoV-2, Healthcare workers, Seroprevalence, 【초록키워드】 coronavirus, antibody, Variation, Sex, healthcare worker, Prevalence, Serosurvey, Immunoglobulin, Sensitivity and specificity, HCWs, SARS-CoV-2 spike protein, Kenya, age, estimates, HCW, acute respiratory syndrome, 95% CI, no difference, multivariable model, enzyme-linked immunosorbent, initial, Result, tested, significantly, recruited, conducted, adjusted, 【제목키워드】 coronavirus 2, Kenya, respiratory, worker,