Summary SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Here, we used systems serology to characterize the Fc profile of influenza-, pertussis-, and SARS-CoV-2-specific antibodies transferred across the placenta. Influenza- and pertussis-specific antibodies were actively transferred. However, SARS-CoV-2-specific antibody transfer was significantly reduced compared to influenza- and pertussis-specific antibodies, and cord titers and functional activity were lower than in maternal plasma. This effect was only observed in third-trimester infection. SARS-CoV-2-specific transfer was linked to altered SARS-CoV-2-antibody glycosylation profiles and was partially rescued by infection-induced increases in IgG and increased FCGR3A placental expression. These results point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design. Graphical abstract Highlights • SARS-CoV-2-specific antibodies have a decreased placental transfer • SARS-CoV-2-spike antibodies have altered glycosylation profiles in pregnant women • Pregnant women with SARS-CoV-2 during the third trimester have elevated IgG levels • SARS-CoV-2-specific antibody transfer is efficient after second-trimester infection Atyeo et al. reveal a deficiency in SARS-CoV-2-antibody placental transfer among women infected during the third trimester. While bulk antibody transfer remains unaltered, SARS-CoV-2-antibodies show perturbed Fc glycosylation profiles and elevated IgG and FCGR3A placental expression that suggest compensation for poor transfer.
【저자키워드】 antibodies, SARS-CoV-2, Inflammation, glycosylation, Infection, Pregnancy, placental transfer, Fc-receptor, fucose, hypergammablobulinemia, trimester, 【초록키워드】 IgG, Immunity, Placenta, serology, antibody, Influenza, SARS-COV-2 infection, Vaccine design, Infant, pregnant women, Maternal, Neonates, placental, women, expression, mechanism, severe disease, antibody transfer, influenza-, compensatory mechanism, deficiency, SARS-CoV-2-specific antibody, Abstract, profile, transfer, maternal plasma, while, boost immunity, FCGR3A, significantly, elevated, reduced, functional, changes in, cause, rescued, increases in, IgG level, transferred, 【제목키워드】 placental, antibody transfer, Compromised,