Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways mucosa 37 patients who were suspected of COVID-19. According to the RT-PCR results, the patients were separated into three groups: negative for COVID-19 and other viruses (NEGS, n = 5); negative for COVID-19 but positive for the presence of other viruses (OTHERS, n = 5); and the positive for COVID-19 (COVID-19, n = 27). Higher specific-SIgA for SARS-CoV-2, IFN-β, and IFN-γ were found in the COVID-19 group than in the other groups. Increased IL-12p70 levels were observed in OTHERS group as compared to COVID-19 group. When the COVID-19 group was sub stratified according to the illness severity, significant differences and correlations were found for the same parameters described above comparing severe COVID-19 to the mild COVID-19 group and other non-COVID-19 groups. For the first time, significant differences are shown in the airway’s mucosa immune responses in different groups of patients with or without respiratory SARS-CoV-2 infection.
【저자키워드】 viruses, SARS-CoV-2, respiratory, cytokine-immunological terms, mucosal immmunity, secretory immunoglobulin A, 【초록키워드】 COVID-19, immune response, severe COVID-19, SARS-COV-2 infection, cytokine, RT-PCR, virus, airway, Immunoglobulin, Patient, Mild, correlation, group, IFN-γ, mucosa, Illness severity, Non-COVID-19, significant difference, IFN-β, viral respiratory diseases, COVID-19 group, positive, IL-12p70, parameter, SIgA, local immune response, shown, described, include, the patient, investigated, elicit, groups, Increased, stratified, separated, 【제목키워드】 IgA, response, IFN,