Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of the major complications in COVID-19 patients. Dysregulation of the immune system and imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2 infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting COVID-19-associated severe ARDS has been analyzed using functional proteomics approaches. Both, innate and humoral responses have been characterized through acute-phase protein network and auto-antibody signature. Severity and sepsis by SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define their clinical progression, which could provide novel perspectives in therapeutics development and biomarkers of COVID-19 patients. Humoral response in COVID-19 patients’ profile separates with significant differences patients with or without ARDS. Furthermore, we found that this profile can be correlated with COVID-19 severity and results more common in elderly patients.
【저자키워드】 COVID-19, SARS-CoV-2, proteomics, ARDS, Microarrays, Antigen, Auto-antibodies, Acute-phase proteins, 【초록키워드】 Biomarker, SARS-COV-2 infection, severity, Sepsis, progression, immune system, elderly patients, Protein, Humoral response, Patient, Complication, COVID-19 patients, Inflammatory, Immune cell, distress, Activation, significant difference, profile, approaches, Perspective, severe ARDS, syndrome, severe pulmonary disease, cytokine release, analyzed, involved, characterized, functional, correlated, presenting, with COVID-19, 【제목키워드】 response, Trigger,