In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
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【저자키워드】 Gene therapy, immune reconstitution, Primary immunodeficiencies, Wiskott-Aldrich Syndrome, severe acute respiratory syndrome Coronavirus 2 (2019-nCoV), 【초록키워드】 Treatment, SARS-CoV-2, therapy, SARS-COV-2 infection, Infection, immune, Immunoglobulin, cells, Patient, Mild, neutralizing capacity, expression, autoinflammatory disease, clinical phenotype, inflammatory complications, Course, produced, resulting, affected, the patient, 【제목키워드】 SARS-CoV-2, Child, report,
【저자키워드】 Gene therapy, immune reconstitution, Primary immunodeficiencies, Wiskott-Aldrich Syndrome, severe acute respiratory syndrome Coronavirus 2 (2019-nCoV), 【초록키워드】 Treatment, SARS-CoV-2, therapy, SARS-COV-2 infection, Infection, immune, Immunoglobulin, cells, Patient, Mild, neutralizing capacity, expression, autoinflammatory disease, clinical phenotype, inflammatory complications, Course, produced, resulting, affected, the patient, 【제목키워드】 SARS-CoV-2, Child, report,
이 연구에서 우리는 유전자 요법으로 치료한 지 5개월 후에 발생한 자가염증성 질환의 이전 병력이 있는 심각한 Wiskott-Aldrich 증후군에 걸린 1.5세 소년의 SARS-CoV-2 감염 사례를 제시합니다. SARS-CoV-2 감염 이전에 환자는 유전자 수정된 세포의 생착을 획득하여 WASP 발현 회복 및 조기 면역 재구성을 초래했습니다. 환자는 중화 능력이 있는 높은 역가로 SARS-CoV-2에 대한 특정 면역글로불린을 생성했으며 유전자 치료 전 임상 표현형에도 불구하고 염증 합병증이 제한된 경미한 감염 과정을 경험했습니다.