Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
【저자키워드】 NK cell, T cell, Convalescent plasma (CP), COVID – 19, SARS – CoV – 2, CD19 CAR-T cell, 【초록키워드】 COVID-19, Treatment, coronavirus disease, convalescent plasma, Cellular immune response, virus, B cell, Convalescent plasma therapy, Patient, Clinical studies, SARS-CoV-2 infections, COVID-19 patients, natural killer cell, CD19, CAR-T cell therapy, These data, virus clearance, described, the disease, correlated, activate, virus-specific T cell, 【제목키워드】 T cell, expansion, CD19, induced, CAR, Deficient,