Adult-onset immunodeficiency syndrome due to anti-interferon (IFN)-γ autoantibodies has attracted much attention in recent years. It usually occurs in previously healthy people and usually presents as chronic, recurrent, and hard-to-control infections that can be effectively treated with aggressive antibiotic therapy. Adult-onset immunodeficiency syndrome is also referred to as AIDS-like syndrome. Anti-type I IFN (IFN-I) autoantibodies have been reported to play a significant role in the pathogenesis of coronavirus disease 2019 (COVID-19) and preexisting anti-IFN-I autoantibodies are associated with an increased risk of severe COVID-19. This review summarizes the effects of anti-IFN autoantibodies on the susceptibility and severity of various infectious diseases, including SARS-CoV-2 infection. In addition, we discuss the role of anti-IFN autoantibodies in the pathogenesis of autoimmune diseases that are characterized by recurrent infections.
【저자키워드】 Infectious disease, Autoimmune disease, coronavirus disease 2019 pneumonia, adult-onset immunodeficiency syndrome, autoantibodies against IFNs, 【초록키워드】 COVID-19, coronavirus disease, Diseases, Pathogenesis, severe COVID-19, SARS-COV-2 infection, susceptibility, severity, Infection, immunodeficiency, infections, IFN-I, IFN, autoantibody, Antibiotic therapy, increased risk, syndrome, Effect, healthy, reported, addition, characterized, treated, occur, 【제목키워드】 COVID-19,